MicroRNA-204 targets JAK2 in breast cancer and induces cell apoptosis through the STAT3/BCl-2/survivin pathway.

摘要: MicroRNAs (miRNAs) have emerged as important regulators that potentially play critical roles in cancer cell biological processes. Previous studies shown miR-204 plays an role various human cancers. However, the underlying mechanisms of this microRNA breast remain largely unknown. In present study, we investigated expression level was markedly reduced both tissue and cultured lines (MCF-7, MDA-MB-231). Overexpression inhibited proliferation promoted apoptosis cells, which were reversed by co-transfection inhibitor. We validated Janus kinase 2 (JAK2), a direct target miR-204, is overexpressed cancer. Knockdown JAK2 suppressed viability induced cells. Moreover, negatively correlated with p-STAT3 anti-apoptotic genes BCl-2 surviving conclusions, targets p-JAK2 cancer, further inhibit activation STAT3, survivin. These findings indicate manipulation may represent novel therapeutic strategy treatment