Muscle redox signalling pathways in exercise. Role of antioxidants

摘要: Recent research highlights the importance of redox signalling pathway activation by contraction-induced reactive oxygen species (ROS) and nitric oxide (NO) in normal exercise-related cellular molecular adaptations skeletal muscle. In this review, we discuss some potentially important pathways muscle that are involved acute chronic responses to contraction exercise. Specifically, implicated force, mitochondrial biogenesis antioxidant enzyme induction, glucose uptake hypertrophy. Furthermore, review evidence investigating impact major exogenous antioxidants on these Redox adaptive exercise not clearly elucidated at present, further is required better define involved. Evidence beneficial or detrimental effects specific compounds similarly limited, particularly human subjects. Future only investigate adaptations, but also establish mechanisms action vivo. Although feel it remains somewhat premature make clear recommendations relation application different settings, a bulk suggests N-acetylcysteine (NAC) ergogenic through its maintenance force production during sustained fatiguing events. Nevertheless, current lack from studies using performance tests representative athletic competition potential for adverse with high doses (>70mg/kg body mass) warrants caution use enhancement. addition, implicates dose vitamin C (1g/day) E (≥260 IU/day) supplementation impairments training. Thus, determining utility athletes likely requires consideration training periodization cycles addition type, duration supplementation.