Effects of vitamin C and E supplementation on endogenous antioxidant systems and heat shock proteins in response to endurance training

摘要: Reactive oxygen and nitrogen species are important signal molecules for adaptations to training. Due the antioxidant properties of vitamin C E, supplementation has been shown blunt endurance In this study, we investigated effects E training on in endogenous antioxidants heat shock proteins (HSP). Thirty seven males females were randomly assigned receive Vitamin (C + E; C: 1000 mg, E: 235 mg daily) or placebo (PLA), underwent 11 weeks. After 5 weeks, a subgroup conducted high intensity interval session investigate acute stress responses. Muscle blood samples obtained changes mRNA related HSP system. The response revealed no NFκB activation. However, higher responses exercise group was indicated by larger translocation HSPs more pronounced gene expression compared PLA. Eleven weeks decreased muscle GPx1, HSP27 αB-crystallin, while mnSOD, HSP70 GSH remained unchanged, with influence supplementation. Plasma increased both groups, uric acid only. Our results showed that did not affect long-term antioxidant- systems. greater might indicate occurs through different mechanisms two groups.