Antioxidants prevent health-promoting effects of physical exercise in humans.

作者: M. Ristow , K. Zarse , A. Oberbach , N. Kloting , M. Birringer

DOI: 10.1073/PNAS.0903485106

关键词:

摘要: … Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise … whether they affect the health-promoting effects of exercise is unknown. …

参考文章(35)
Nicholas Houstis, Evan D. Rosen, Eric S. Lander, Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature. ,vol. 440, pp. 944- 948 ,(2006) , 10.1038/NATURE04634
DAVID E. KELLEY, BRET H. GOODPASTER, Effects of physical activity on insulin action and glucose tolerance in obesity. Medicine and Science in Sports and Exercise. ,vol. 31, ,(1999) , 10.1097/00005768-199911001-00021
John O Holloszy, Longevity of exercising male rats: effect of an antioxidant supplemented diet Mechanisms of Ageing and Development. ,vol. 100, pp. 211- 219 ,(1998) , 10.1016/S0047-6374(97)00140-1
Natalie C Ward, Jason HY Wu, Michael W Clarke, Ian B Puddey, Valerie Burke, Kevin D Croft, Jonathan M Hodgson, The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Journal of Hypertension. ,vol. 25, pp. 227- 234 ,(2007) , 10.1097/01.HJH.0000254373.96111.43
James P. McClung, Carol A. Roneker, Weipeng Mu, Donald J. Lisk, Paul Langlais, Feng Liu, Xin Gen Lei, Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 8852- 8857 ,(2004) , 10.1073/PNAS.0308096101
David K. Simon, Robert Bachoo, Bruce M. Spiegelman, Julie St-Pierre, Stavit Drori, Marc Uldry, Jessica M. Silvaggi, James Rhee, Sibylle Jäger, Christoph Handschin, Kangni Zheng, Jiandie Lin, Wenli Yang, Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators Cell. ,vol. 127, pp. 397- 408 ,(2006) , 10.1016/J.CELL.2006.09.024
Paul Zimmet, K. G. M. M. Alberti, Jonathan Shaw, Global and societal implications of the diabetes epidemic Nature. ,vol. 414, pp. 782- 787 ,(2001) , 10.1038/414782A
M. Higuchi, L.-j. Cartier, M. Chen, J. O. Holloszy, Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise. Journal of Gerontology. ,vol. 40, pp. 281- 286 ,(1985) , 10.1093/GERONJ/40.3.281
Mary Elizabeth Patti, Atul J. Butte, Sarah Crunkhorn, Kenneth Cusi, Rachele Berria, Sangeeta Kashyap, Yoshinori Miyazaki, Isaac Kohane, Maura Costello, Robert Saccone, Edwin J. Landaker, Allison B. Goldfine, Edward Mun, Ralph DeFronzo, Jean Finlayson, C. Ronald Kahn, Lawrence J. Mandarino, Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 8466- 8471 ,(2003) , 10.1073/PNAS.1032913100