N-Acetylcysteine's attenuation of fatigue after repeated bouts of intermittent exercise: practical implications for tournament situations.

摘要: Production of reactive oxygen species (ROS) during muscle contractions is associated with fatigue and damage in the short term adaptive responses long term. When adaptation inconsequential acute antioxidant supplementation may be able to attenuate enhance performance. This study aimed determine effects oral N-acetylcysteine (NAC) on Yo-Yo Intermittent Recovery Test Level 1 (YIRT-L1) performance after repeated bouts damaging intermittent exercise. In a pair-matched design, 12 recreationally trained men engaged 6 d either NAC (n = 6) or placebo supplementation. After treatment-loading day, participants completed 3 testing sessions, alternating days, consisting preexercise isokinetic dynamometry (IKD) test, intermittent-exercise protocol, YIRT-L1, postexercise IKD test. Another test was 2 intervening d. treatment resulted significant preservation YIRT-L1 (p .0005). significantly deteriorated over time at all contraction speeds, this deterioration not influenced by group. Plasma creatine kinase values increased .002) were greater group than .029). induced mild gastrointestinal side effects. useful strategy short-term competitive situations when adaption inconsequential. Titration studies elucidate dose that enhances without inducing are now required.