Protecting the kidneys in lupus nephritis

作者: Samir Parikh , Lee Hebert , Brad Rovin

DOI: 10.2217/IJR.11.47

关键词:

摘要: Kidney involvement is common in systemic lupus erythematosus. The inciting event nephritis immune complex accumulation the kidneys. While this process triggers kidney damage erythematosus, hemodynamic and metabolic factors activated after initial promote chronic, progressive to kidney. Systemic intraglomerular hypertension, proteinuria, hyperlipidemia, hyperuricemia, uremic acidosis vitamin D deficiency have all been found contribute progression of disease. aim renal protective therapies suppress these secondary thereby retard disease both active inactive glomerular with residual chronic This can be effectively accomplished through a combination medications, dietary interventions lifestyle changes. article discuss nonimmune that will help nephritis.

参考文章(123)
Inseey Kanjanakul, Ouppatham Supasyndh, Bancha Satirapoj, Panbuppa Choovichian, Duangporn Phulsuksombuti, Naowanit Nata, Krisada Duangurai, Darunee Utennam, High levels of uric acid correlate with decline of glomerular filtration rate in chronic kidney disease. Journal of the Medical Association of Thailand Chotmaihet thangphaet. ,vol. 93, pp. 65- ,(2010)
Telmisartan, ramipril, or both in patients at high risk of vascular events. The New England Journal of Medicine. ,vol. 359, pp. 426- ,(2008) , 10.1056/NEJMC081065
Ulrike Raff, Thomas K Schwarz, Markus P Schneider, Roland E Schmieder, Diana Hummel, Bernhard M W Schmidt, Dihydropyridine calcium antagonists are associated with increased albuminuria in treatment-resistant hypertensives Journal of Nephrology. ,vol. 23, pp. 563- ,(2010)
Jiang He, P. K. Whelton, Elevated systolic blood pressure as a risk factor for cardiovascular and renal disease. Journal of Hypertension. ,vol. 17, ,(1999)
Bénédicte Stengel, Cécile Couchoud, Sylvie Cénée, Denis Hémon, Age, blood pressure and smoking effects on chronic renal failure in primary glomerular nephropathies. Kidney International. ,vol. 57, pp. 2519- 2526 ,(2000) , 10.1016/S0085-2538(15)47011-5
Margherita T Cantorna, Yan Zhu, Monica Froicu, Anja Wittke, Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system The American Journal of Clinical Nutrition. ,vol. 80, ,(2004) , 10.1093/AJCN/80.6.1717S
Jaime Uribarri, ACID‐BASE IN RENAL FAILURE: Acidosis in Chronic Renal Insufficiency Seminars in Dialysis. ,vol. 13, pp. 232- 234 ,(2001) , 10.1046/J.1525-139X.2000.00064.X
Lawrence G. Hunsicker, , Sharon Adler, Arlene Caggiula, Brian K. England, Tom Greene, John W. Kusek, Nancy L. Rogers, Paul E. Teschan, Gerald Beck, Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study Kidney International. ,vol. 51, pp. 1908- 1919 ,(1997) , 10.1038/KI.1997.260