Prevention of Contrast Nephropathy by Furosemide With Matched Hydration

摘要: Objectives This study investigated the effect of furosemide-forced diuresis and intravenous saline infusion matched with urine output, using a novel dedicated device designed for contrast-induced nephropathy (CIN) prevention. Background CIN is frequent cause acute kidney injury associated increased morbidity mortality. Methods A total 170 consecutive patients chronic disease (CKD) undergoing coronary procedures were randomized to either furosemide hydration (FMH group, n = 87) or standard isotonic (control group; 83). The FMH group received an initial 250-ml bolus normal over 30 min followed by (0.5 mg/kg) furosemide. Hydration rate was automatically adjusted precisely replace patient's output. When output >300 ml/h obtained, underwent procedure. Matched fluid replacement maintained during procedure 4 h post-treatment. definition ≥25% ≥0.5 mg/dl rise in serum creatinine baseline. Results In no device- therapy-related complications observed. Four (4.6%) developed versus 15 (18%) controls (p 0.005). lower incidence cumulative in-hospital clinical also observed FMH-treated than (8% vs. 18%; p 0.052). Conclusions CKD procedures, furosemide-induced high significantly reduces risk may be improved outcome. (Induced Diuresis With Compared Standard Contrast Induced Nephropathy Prevention [MYTHOS]; NCT00702728 )