Protective effects of extracellular polymeric substances from Aphanizomenon flos-aquae on neurotoxicity induced by local anesthetics.

作者: Xing Xue , Ying Lv , Yufang Leng , Yan Zhang

DOI: 10.3892/ETM.2018.6540

关键词:

摘要: The neurotoxicity of local anesthetics has received an increasing amount of attention and more effective therapeutic agents are required. Extracellular polymeric substances from Aphanizomenon flos‑aquae (EPS‑A) are high molecular weight polysaccharides. The present study aimed to elucidate the protective effects of EPS‑A on neurotoxicity induced by local anesthetics in an intraperitoneal injection bupivacaine rat model. The results of immunohistochemical staining inicated that following intraperitoneal injection of EPS‑A the …

参考文章(40)
Tae Y Yune, Sun J Kim, Sang M Lee, Young K Lee, Young J Oh, Young C Kim, George J Markelonis, Tae H Oh, None, Systemic Administration of 17β-Estradiol Reduces Apoptotic Cell Death and Improves Functional Recovery following Traumatic Spinal Cord Injury in Rats Journal of Neurotrauma. ,vol. 21, pp. 293- 306 ,(2004) , 10.1089/089771504322972086
XING XUE, YING LV, QING LIU, XIAOLAN ZHANG, YOUHONG ZHAO, LILI ZHANG, SHIYUAN XU, Extracellular polymeric substance from Aphanizomenon flos-aquae induces apoptosis via the mitochondrial pathway in A431 human epidermoid carcinoma cells. Experimental and Therapeutic Medicine. ,vol. 10, pp. 927- 932 ,(2015) , 10.3892/ETM.2015.2644
Rong Zeng, Jing He, Jin Peng, Yan Chen, Sha Yi, Fei Zhao, Guohui Cui, The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion. Annals of Hematology. ,vol. 91, pp. 407- 417 ,(2012) , 10.1007/S00277-011-1315-Z
Igor A. Schepetkin, Mark T. Quinn, Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential International Immunopharmacology. ,vol. 6, pp. 317- 333 ,(2006) , 10.1016/J.INTIMP.2005.10.005
Yu-Lin Kang, Moin Ahson Saleem, Kwok Wah Chan, Benjamin Yat-Ming Yung, Helen Ka-Wai Law, Trehalose, an mTOR Independent Autophagy Inducer, Alleviates Human Podocyte Injury after Puromycin Aminonucleoside Treatment PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0113520
Noboru Mizushima, Masaaki Komatsu, Autophagy: Renovation of Cells and Tissues Cell. ,vol. 147, pp. 728- 741 ,(2011) , 10.1016/J.CELL.2011.10.026
Mengjing Xiao, Ligen Li, Chenxi Li, Peirong Zhang, Quan Hu, Li Ma, Haijun Zhang, Role of Autophagy and Apoptosis in Wound Tissue of Deep Second‐degree Burn in Rats Academic Emergency Medicine. ,vol. 21, pp. 383- 391 ,(2014) , 10.1111/ACEM.12352
C.J. Park, S.A. Park, T.G. Yoon, S.J. Lee, K.W. Yum, H.J. Kim, Bupivacaine Induces Apoptosis via ROS in the Schwann Cell Line Journal of Dental Research. ,vol. 84, pp. 852- 857 ,(2005) , 10.1177/154405910508400914