Asymmetric Autocatalysis with Amplification of Chirality

摘要: We found that chiral 5-pyrimidyl alkanols are highly enantioselective asymmetric autocatalysts forthe addition of i-Pr2Zn to the corresponding aldehyde.Asymmetric autocatalysis with amplification ee from extremely low (0.00005%) >99.5% wasrealized for first time by consecutive autocatalysis. The chirality CPL was directlycorrelated pyrimidyl alkanol high photodegradation theracemic in combination Chiral inorganic crystals suchas quartz act as triggers and regulate sense organiccrystals composed an achiral compound such hippuric acid initial source forasymmetric produce nearly enantiomerically pure product. Highly sensitive discriminationof amino acids is described. Direct examination extraterrestrial performedon meteorites applying sensor. Spontaneous absolute asymmetricsynthesis described formation enriched reactionof pyrimidine-5-carbaldehyde withoutadding any substance Asymmetric a chiralpyrimidyl only possible method discriminate cryptochiral quaternary saturated hydrocarbon,whose not capable determination current method. discrimination chiralitydue deuterium substitution also accessible