Asymptomatic avascular necrosis in patients with primary antiphospholipid syndrome in the absence of corticosteroid use: A prospective study by magnetic resonance imaging

摘要: Objective To evaluate the prevalence of avascular necrosis (AVN), using magnetic resonance imaging (MRI), in patients with primary antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE), or without anticardiolipin antibodies (aCL), who are asymptomatic for AVN have not taken corticosteroids. Methods Seventy-nine subjects were evaluated by MRI femoral heads: 30 APS had never received corticosteroids, 19 SLE steroids (divided into 2 groups, aCL positive negative, order to examine any association between aCL), healthy age- sex-matched APS. Established criteria used a diagnosis AVN. Results Asymptomatic was evident 6 (20%) APS: 3 them (1 man, women) intermediate bilateral AVN, (all early (bilateral 1 patient). Results hip pelvis radiography dynamic scintigraphy negative. Followup months later revealed no changes. At time initial examination, mean (±SD) age whom identified 31.2 ± 7.3 years, that 42.4 11.9 years (P = 0.036). Livedo reticularis occurred significantly more commonly group 0.041). None none demonstrated on MRI. Conclusion AVN can be detected 20% Younger tend develop frequently than do older patients, presence livedo may identify individuals at risk AVN. Clinicians should aware this possible clinical manifestation APS, because lead intervention.