Non-cGMP, Paracrine Effects of Nitric Oxide in the Vasculature
作者： Nancy L. Kanagy , Rajabrata Sarkar , Stephanie W. Watts , R. Clinton Webb
DOI: 10.1007/978-1-4612-0231-8_3
关键词:
摘要: Nitric oxide (NO) is as an important endogenous modulator of blood vessel function (1,2). NO released from vascular endothelial cells acts in a paracrine fashion on adjacent smooth muscle (VSMC) to activate soluble guanylyl cyclase and generate cyclic guanosine 3’,5’ monophosphate (cGMP) (2). cGMP, turn, mediates many NO-mediated actions VSMC. However, number cGMP-independent effects have been observed following stimulation, indicating that activation accounts for only portion the NO.
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