No impact of interleukin-28B polymorphisms on spontaneous or drug-induced hepatitis delta virus clearance

摘要: Abstract Background rs12979860 and rs8099917 interleukin-28B polymorphisms are associated with spontaneous or interferon-alpha induced hepatitis C clearance, “CC” “TT” genotypes (respectively) being the most favourable. There no data on influence of delta clearance in B/D co-infected patients. Aims The present study explores potential both infection outcome. Methods Retrospective-longitudinal 55 European patients observed for at least 4 years, selected from a cohort 439 subjects positive antibodies B core antibodies. rate interferon delta-RNA was compared vs “non CC”, TT” genotypes. Results Prevalence rs12979860 C allele 60%, consistent reported prevalence Italy (67%, p = 0.128). No significant differences were between CC” (13.3% 7.5%, respectively, p = 0.60), “non-TT” (11.1 7.1%, p = 0.67). interferon-induced either. Conclusions Our suggest that might not either natural history response.