Clinical outcome of acute and chronic hepatitis delta over time: a long-term follow-up study.

摘要: Long-term changes in the frequency and outcome of hepatitis delta virus (HDV) infection have seldom been analysed. This retrospective, longitudinal study includes 398 consecutive B surface antigen (HBsAg)-positive patients with anti-HDV antibodies who attended our institution between 1983 2008. At enrolment, 182 had acute 216 chronic hepatitis. Patients were grouped into two periods. Those 1995 those 1996 The former group was significantly younger, mainly intravenous drugs users, a greater incidence HDV HIV HCV coinfection. HBV/HDV coinfection cleared both infections 90% cases, while all superinfection evolved to disease. One hundred fifty-eight followed for median period 158months. Seventy-two per cent remained stable, 18% hepatic decompensation, 3% developed hepatocellular carcinoma, 8% HBsAg. Liver-related death observed 13% occurred from first (P=0.012). These results indicate an outbreak at end 1980s beginning 1990s, large number cases affecting predominately young, male drug users. Currently, disease are older, factors associated worse prognosis include presence cirrhosis age time diagnosis.