High values of Th1 (CXCL10) and Th2 (CCL2) chemokines in patients with psoriatic arthtritis.
作者： A Delle Sedie , Lucrezia Riente , Alessandro Antonelli , Stefano Bombardieri , Eleuterio Ferrannini
DOI:
关键词:
摘要: Objective To evaluate serum levels of CXCL10 and CCL2 in a large series PsA patients, to relate chemokines the clinical phenotype these patients. Methods Serum were measured 68 gender- age-matched (1:1) controls drawn from general population. Results patients showed significantly (p 198 pg/ml), 49% with 5% control subjects had high 730 19% PsA, 2% (p<0.001; chi-square=22.02). Conclusion In conclusion, circulating have been found Th1 immune predominance early phase disease. A decline has observed long lasting significant increase CCL2/CXCL10 ratio, suggesting shift Th2 response duration PsA.
参考文章(38)
H S El-Gabalawy, R F Hynd, P Szodoray, I M Dozmorov, M Centola, M B Frank, N Knowlton, A Kumar, P Alex, M Turner, L Willis, C Carson, R E Arthur, D Flinn, Multiplex serum cytokine monitoring as a prognostic tool in rheumatoid arthritis Clinical and Experimental Rheumatology. ,vol. 25, pp. 584- 592 ,(2007)
Albert Zlotnik, Osamu Yoshie, Chemokines: A New Classification System and Their Role in Immunity Immunity. ,vol. 12, pp. 121- 127 ,(2000) , 10.1016/S1074-7613(00)80165-X
Paul Proost, Sofie Struyf, Tamara Loos, Mieke Gouwy, Evemie Schutyser, René Conings, Isabelle Ronsse, Marc Parmentier, Bernard Grillet, Ghislain Opdenakker, Jan Balzarini, Jo Van Damme, Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies. Arthritis Research & Therapy. ,vol. 8, pp. 1- 14 ,(2006) , 10.1186/AR1997
Marco Baggiolini, Chemokines and leukocyte traffic Nature. ,vol. 392, pp. 565- 568 ,(1998) , 10.1038/33340
W J Karpus, N W Lukacs, S D Hurst, K J Kennedy, T A Barrett, W S Smith, Differential CC chemokine-induced enhancement of T helper cell cytokine production. Journal of Immunology. ,vol. 158, pp. 4129- 4136 ,(1997)
Carlo Laudanna, Federica Calzetti, Sara Gasperini, Marco A. Cassatella, Joshua Farber, Henrik Olsen, Lucia Vicentini, Martina Marchi, Marianne Murphy, Fang Liao, Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils Journal of Immunology. ,vol. 162, pp. 4928- 4937 ,(1999)
DD Gladman, V Strand, PJ Mease, C Antoni, P Nash, A Kavanaugh, OMERACT 7 psoriatic arthritis workshop: synopsis Annals of the Rheumatic Diseases. ,vol. 64, pp. ii115- ii116 ,(2005) , 10.1136/ARD.2004.032615
A. Shimada, J. Morimoto, K. Kodama, R. Suzuki, Y. Oikawa, O. Funae, A. Kasuga, T. Saruta, S. Narumi, Elevated Serum IP-10 Levels Observed in Type 1 Diabetes Diabetes Care. ,vol. 24, pp. 510- 515 ,(2001) , 10.2337/DIACARE.24.3.510
Mieke Gouwy, Sofie Struyf, Paul Proost, Jo Van Damme, Synergy in cytokine and chemokine networks amplifies the inflammatory response Cytokine & Growth Factor Reviews. ,vol. 16, pp. 561- 580 ,(2005) , 10.1016/J.CYTOGFR.2005.03.005
Reinhard Gillitzer, Klaus Wolff, Dan. Tong, Christoph Müller, Teizo Yoshimura, Albert A Hartmann, Georg Stingl, Rudolf Berger, MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions. Journal of Investigative Dermatology. ,vol. 101, pp. 127- 131 ,(1993) , 10.1111/1523-1747.EP12363613