Metabolic Control of Longevity
作者： Carlos López-Otín , Lorenzo Galluzzi , José MP Freije , Frank Madeo , Guido Kroemer
DOI: 10.1016/J.CELL.2016.07.031
关键词:
摘要: Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of "metabolic clock" that controls aging. Multiple inborn defects circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each nine hallmarks aging is connected undesirable alterations. The main features "westernized" lifestyle, including hypercaloric nutrition and sedentariness, can as they have detrimental consequences. Conversely, lifespan-extending maneuvers caloric restriction impose beneficial pleiotropic effects on introduction strategies promote fitness may extend healthspan humans.
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Linda Broer, Cornelia M. van Duijn, GWAS and Meta-Analysis in Aging/Longevity. Advances in Experimental Medicine and Biology. ,vol. 847, pp. 107- 125 ,(2015) , 10.1007/978-1-4939-2404-2_5
Dóra Révész, Yuri Milaneschi, Josine E. Verhoeven, Jue Lin, Brenda W. J. H. Penninx, Longitudinal Associations Between Metabolic Syndrome Components and Telomere Shortening The Journal of Clinical Endocrinology and Metabolism. ,vol. 100, pp. 3050- 3059 ,(2015) , 10.1210/JC.2015-1995
Siming Ma, Sun Hee Yim, Sang-Goo Lee, Eun Bae Kim, Sang-Rae Lee, Kyu-Tae Chang, Rochelle Buffenstein, Kaitlyn N. Lewis, Thomas J. Park, Richard A. Miller, Clary B. Clish, Vadim N. Gladyshev, Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity Cell Metabolism. ,vol. 22, pp. 332- 343 ,(2015) , 10.1016/J.CMET.2015.07.005
P. Darrell Neufer, Marcas M. Bamman, Deborah M. Muoio, Claude Bouchard, Dan M. Cooper, Bret H. Goodpaster, Frank W. Booth, Wendy M. Kohrt, Robert E. Gerszten, Mark P. Mattson, Russell T. Hepple, William E. Kraus, Michael B. Reid, Sue C. Bodine, John M. Jakicic, Jerome L. Fleg, John P. Williams, Lyndon Joseph, Mary Evans, Padma Maruvada, Mary Rodgers, Mary Roary, Amanda T. Boyce, Jonelle K. Drugan, James I. Koenig, Richard H. Ingraham, Danuta Krotoski, Mary Garcia-Cazarin, Joan A. McGowan, Maren R. Laughlin, Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits Cell Metabolism. ,vol. 22, pp. 4- 11 ,(2015) , 10.1016/J.CMET.2015.05.011
Noriyuki Fuku, Helios Pareja‐Galeano, Hirofumi Zempo, Rafael Alis, Yasumichi Arai, Alejandro Lucia, Nobuyoshi Hirose, The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? Aging Cell. ,vol. 14, pp. 921- 923 ,(2015) , 10.1111/ACEL.12389
Vasanti S. Malik, Frank B. Hu, Fructose and Cardiometabolic Health Journal of the American College of Cardiology. ,vol. 66, pp. 1615- 1624 ,(2015) , 10.1016/J.JACC.2015.08.025
David A. Hood, Liam D. Tryon, Anna Vainshtein, Jonathan Memme, Chris Chen, Marion Pauly, Matthew J. Crilly, Heather Carter, Exercise and the Regulation of Mitochondrial Turnover Progress in Molecular Biology and Translational Science. ,vol. 135, pp. 99- 127 ,(2015) , 10.1016/BS.PMBTS.2015.07.007
Emanuel E. Canfora, Johan W. Jocken, Ellen E. Blaak, Short-chain Fatty Acids in Control of Body Weight and Insulin Sensitivity Nature Reviews Endocrinology. ,vol. 11, pp. 577- 591 ,(2015) , 10.1038/NRENDO.2015.128
C. Kang, Q. Xu, T. D. Martin, M. Z. Li, M. Demaria, L. Aron, T. Lu, B. A. Yankner, J. Campisi, S. J. Elledge, The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 Science. ,vol. 349, ,(2015) , 10.1126/SCIENCE.AAA5612
Cyrus Jahansouz, Federico J. Serrot, Brigitte I. Frohnert, Rocio E. Foncea, Robert B. Dorman, Bridget Slusarek, Daniel B. Leslie, David A. Bernlohr, Sayeed Ikramuddin, Roux-en-Y Gastric Bypass Acutely Decreases Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue Obesity Surgery. ,vol. 25, pp. 2376- 2385 ,(2015) , 10.1007/S11695-015-1708-5