Immune and inflammatory responses to DNA damage in cancer and aging.
作者： Clara Soria-Valles , Alejandro López-Soto , Fernando G. Osorio , Carlos López-Otín
DOI: 10.1016/J.MAD.2016.10.004
关键词:
摘要: Genome instability is a hallmark of both cancer and aging processes. Beyond cell-autonomous responses, it known that DNA damage also elicits systemic mechanisms aimed at favoring survival damaged cells clearance. Among these mechanisms, immune activation NF-κB-mediated inflammation play central roles in organismal control damage. We focus herein on the different experimental evidences have allowed gaining mechanistic insight about this relationship. describe functional consequences defective function development age-related alterations. Finally, we discuss intervention strategies based enhancing immunity or modulation inflammatory response to improve organism homeostasis aging.
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