Tetracycline Antibiotics in Malaria

摘要: The emergence and rapid extension of Plasmodium falciparum resistance to various antimalarial compounds has gradually limited malaria therapeutic possibilities available clinicians the choice an adapted prophylaxis travellers specific for their destinations. In this context, doxycycline constitutes interesting alternative apart from its counter-indications, occurring primarily in children less than eight years old pregnant women. Already used suc- cessfully treatment association with quinine zones multi-resistances, proven be effective well-tolerated prevention malaria. Resistance not been described until now. listed prophylactic failures are dependent on incorrect observation. mechanisms action doxy- cycline parasite completely elucidated. identification molecular targets would al- low design structural analogues that more active stable.