Acto-myosin reorganization and PAR polarity in C. elegans
作者： C. R. Cowan , A. A. Hyman
DOI: 10.1242/DEV.000513
关键词:
摘要: The symmetry-breaking event during polarization of C. elegans embryos is an asymmetric rearrangement the acto-myosin network, which dictates cell polarity through differential recruitment PAR proteins. sperm-supplied centrosomes are required to initiate this cortical reorganization. Several questions about remain unanswered: how network regulated and does reorganization lead protein distribution? As we discuss, recent studies show that use two GTPases, RHO-1 CDC-42, regulate these steps in establishment. Although CDC-42 control distinct aspects polarization, they function interdependently establishment embryos.
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S Umemoto, A R Bengur, J R Sellers, Effect of multiple phosphorylations of smooth muscle and cytoplasmic myosins on movement in an in vitro motility assay Journal of Biological Chemistry. ,vol. 264, pp. 1431- 1436 ,(1989) , 10.1016/S0021-9258(18)94205-5
Yuh Nung Jan, Lily Yeh Jan, Asymmetric cell division Nature. ,vol. 392, pp. 775- 778 ,(1998) , 10.1038/33854
Gérard Joberty, Clark Petersen, Lin Gao, Ian G. Macara, The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nature Cell Biology. ,vol. 2, pp. 531- 539 ,(2000) , 10.1038/35019573
Thomas D. Pollard, Edward D. Korn, Electron Microscopic Identification of Actin Associated with Isolated Amoeba Plasma Membranes Journal of Biological Chemistry. ,vol. 248, pp. 448- 450 ,(1973) , 10.1016/S0021-9258(19)44393-7
T D Pollard, W F Stafford, M E Porter, Characterization of a second myosin from Acanthamoeba castellanii. Journal of Biological Chemistry. ,vol. 253, pp. 4798- 4808 ,(1978) , 10.1016/S0021-9258(17)30460-X
E M V Pires, S V Perry, Purification and properties of myosin light-chain kinase from fast skeletal muscle. Biochemical Journal. ,vol. 167, pp. 137- 146 ,(1977) , 10.1042/BJ1670137
Aaron F. Severson, Bruce Bowerman, Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans Journal of Cell Biology. ,vol. 161, pp. 21- 26 ,(2003) , 10.1083/JCB.200210171
Kevin Fe O'Connell, Kara N. Maxwell, John O. White, The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote. Developmental Biology. ,vol. 222, pp. 55- 70 ,(2000) , 10.1006/DBIO.2000.9714
ROBERT S. ADELSTEIN, MARY ANNE CONTI, Phosphorylation of platelet myosin increases actin-activated myosin ATPase activity. Nature. ,vol. 256, pp. 597- 598 ,(1975) , 10.1038/256597A0
Olle I. Stendahl, Thomas P. Stossel, Actin-binding protein amplifies actomyosin contraction, and gelsolin confers calcium control on the direction of contraction. Biochemical and Biophysical Research Communications. ,vol. 92, pp. 675- 681 ,(1980) , 10.1016/0006-291X(80)90386-1