Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents
作者： Nadjet Rezki , Amjad Al-Yahyawi , Sanaa Bardaweel , Fawzia Al-Blewi , Mohamed Aouad
DOI: 10.3390/MOLECULES200916048
关键词:
摘要: In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized characterized by IR, ¹H-NMR, (13)C-NMR, MS elemental analyses. All compounds screened for their antibacterial, antifungal antiproliferative activity. Some have displayed promising biological
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Radha Raman Gupta, Mahendra Kumar, Vandana Gupta, Five-Membered Heterocycles with More than Two Heteroatoms Springer, Berlin, Heidelberg. pp. 487- 578 ,(1999) , 10.1007/978-3-662-07757-3_5
Mohamed Reda Aouad, Mouslim Messali, Nadjet Rezki, Adeeb Al-Sheikh Ali, Alain Lesimple, Synthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents Acta Pharmaceutica. ,vol. 65, pp. 117- 132 ,(2015) , 10.1515/ACPH-2015-0011
Yan Zou, Qingjie Zhao, Jun Liao, Honggang Hu, Shichong Yu, Xiaoyun Chai, Mingjuan Xu, Qiuye Wu, New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies. Bioorganic & Medicinal Chemistry Letters. ,vol. 22, pp. 2959- 2962 ,(2012) , 10.1016/J.BMCL.2012.02.042
Qing Li, Jianming Ren, Fang Dong, Yan Feng, Guodong Gu, Zhanyong Guo, Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives Carbohydrate Research. ,vol. 373, pp. 103- 107 ,(2013) , 10.1016/J.CARRES.2013.03.001
Gerardo Palla, Giovanni Predieri, Paolo Domiano, Carlo Vignali, Walter Turner, Conformational behaviour and E/Z isomerization of N-acyl and N-aroylhydrazones Tetrahedron. ,vol. 42, pp. 3649- 3654 ,(1986) , 10.1016/S0040-4020(01)87332-4
Olcay Bekircan, Murat Küxük, Bahittin Kahveci, Sevgi Kolaylı, Convenient synthesis of fused heterocyclic 1,3,5-triazines from some N-acyl imidates and heterocyclic amines as anticancer and antioxidant agents. Archiv Der Pharmazie. ,vol. 338, pp. 365- 372 ,(2005) , 10.1002/ARDP.200400964
Dalip Kumar, N. Maruthi Kumar, Kuei-Hua Chang, Kavita Shah, Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles. European Journal of Medicinal Chemistry. ,vol. 45, pp. 4664- 4668 ,(2010) , 10.1016/J.EJMECH.2010.07.023
Gülhan Turan-Zitouni, Zafer Asim Kaplancikli, Ahmet Özdemir, Pierre Chevallet, Hilmi Burak Kandilci, Bülent Gümüsel, Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents. Archiv Der Pharmazie. ,vol. 340, pp. 586- 590 ,(2007) , 10.1002/ARDP.200700134
Harish RAJAK, Murli Dhar KHARYA, Pradeep MISHRA, Synthesis of some novel oxadiazole and oxadiazoline analogues for their antiinflammatory activity. Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan. ,vol. 127, pp. 1757- 1764 ,(2007) , 10.1248/YAKUSHI.127.1757
G.V. Suresh Kumar, Y. Rajendraprasad, B.P. Mallikarjuna, S.M. Chandrashekar, C. Kistayya, Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents European Journal of Medicinal Chemistry. ,vol. 45, pp. 2063- 2074 ,(2010) , 10.1016/J.EJMECH.2010.01.045