Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis
作者： Zheng Yang , Nianyu Huang , Bang Xu , Wenfeng Huang , Tianpeng Xie
DOI: 10.3390/MOLECULES21030232
关键词: Protein kinase B 、 Phosphorylation 、 Stereochemistry 、 Biochemistry 、 Total synthesis 、 Cytotoxicity 、 Penicillium 、 Thiazole 、 Thiadiazoles 、 Biology 、 Acrida cinerea
摘要: Two new thiazole and thiadiazole alkaloids, penicilliumthiamine A B (2 3), were isolated from the culture broth of Penicillium oxalicum, a fungus found in Acrida cinerea. Their structures elucidated mainly by spectroscopic analysis, total synthesis X-ray crystallographic analysis. Biological evaluations indicated that compound 1, 3a 3 exhibit potent cytotoxicity against different cancer cell lines through inhibiting phosphorylation AKT/PKB (Ser 473), one important drugs target.
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