Biological and pharmacological activities of 1,3,4-thiadiazole based compounds.

摘要: The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method the synthesis different 2,5-disubstituted includes cyclization appropriate linear organic derivatives. They are widely known as compounds with various kinds biological activities showing anticancer properties against human cancers acting diuretic, antibacterial, antifungal, antitubercular leishmanicidal agents. Many them influence on OUN exhibiting anticonvulsant, anti-inflammatory, antidepressant, analgesic anxiolytic effects. molecular target following enzymes: carbonic anhydrase (CA), cyclooxygenase (CO), neutral endopeptidase (NEP), aminopeptidase N (APN), matrix metalloproteinases (MMPs), phosphodiesterases (PDEs) c-Src/Abl tyrosine kinase. In this presentation, recent achievements in medicinal 1,3,4-thiadiazole based reviewed.