Presence of matrix metalloproteinase-2 and tissue inhibitor matrix metalloproteinase-2 gene polymorphisms and immunohistochemical expressions in intracranial meningiomas.
作者： İlker Coven , Ozge Ozer , Ozlem Ozen , Feride İffet Şahin , Nur Altinors
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摘要: Object Meningiomas are benign extraaxial tumors with a slow progression. Some of them, in spite being nature, may show an aggressive progression pattern. To investigate the behavioral characteristics meningiomas, researchers have studied matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), interstitial collagens, proteins, vascular endothelial growth factors (VEGF), and tumor necrosis factors. Methods In this study, authors investigated MMP2 TIMP2 gene polymorphisms formalin-fixed paraffin-embedded samples obtained from meningioma patients who had previously undergone surgery at authors' institution. addition, brain invasion, Ki-67 index, MMP-2 TIMP-2 expressions were using immunohistochemical methods. (735C>T, 1575G>A, 1306C>T) (418G>C, 303C>T) sections polymerase chain reaction–restriction fragment length polymorphism method. Results Ther...
sci-hub.se 参考文章(25)
B Demirhan, N Altinörs, O Ozen, Correlation between histological grade and MIB-1 and p53 immunoreactivity in meningiomas. Clinical Neuropathology. ,vol. 24, pp. 219- 224 ,(2005)
Zarin Kachra, Edith Beaulieu, Louis Delbecchi, Nathalie Mousseau, France Berthelet, Robert Moumdjian, Rolando Del Maestro, Richard Béliveau, Expression of matrix metalloproteinases and their inhibitors in human brain tumors. Clinical & Experimental Metastasis. ,vol. 17, pp. 555- 566 ,(1999) , 10.1023/A:1006760632766
William G. Stetler‐Stevenson, Lance A. Liotta, David E. Kleiner, Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. The FASEB Journal. ,vol. 7, pp. 1434- 1441 ,(1993) , 10.1096/FASEBJ.7.15.8262328
Rainer B�schges, Jan Bostr�m, Marietta Wolter, Britta Blaschke, Ruthild G. Weber, Peter Lichter, V. Peter Collins, Guido Reifenberger, Analysis of human meningiomas for aberrations of the MADH2, MADH4, APM-1 and DCC tumor suppressor genes on the long arm of chromosome 18 International Journal of Cancer. ,vol. 92, pp. 551- 554 ,(2001) , 10.1002/IJC.1219
L. Maes, E. Lippens, J. P. O. Kalala, L. de Ridder, The hTERT-protein and Ki-67 labelling index in recurrent and non-recurrent meningiomas. Cell Proliferation. ,vol. 38, pp. 3- 12 ,(2005) , 10.1111/J.1365-2184.2005.00325.X
Masaki Okada, Keisuke Miyake, Yoshihito Matsumoto, Nobuyuki Kawai, Katsuzo Kunishio, Seigo Nagao, Matrix metalloproteinase-2 and matrix metalloproteinase-9 expressions correlate with the recurrence of intracranial meningiomas. Journal of Neuro-oncology. ,vol. 66, pp. 29- 37 ,(2004) , 10.1023/B:NEON.0000013474.01161.58
Ann-Christin Sandberg Nordqvist, Hubert Smurawa, Tiit Mathiesen, Expression of matrix metalloproteinases 2 and 9 in meningiomas associated with different degrees of brain invasiveness and edema. Journal of Neurosurgery. ,vol. 95, pp. 839- 844 ,(2001) , 10.3171/JNS.2001.95.5.0839
HARCHARAN K Rooprai, TIMOTHY Van Meter, GARRY J Rucklidge, LANCE Hudson, IP Everall, GEOFFREY J Pilkington, None, Comparative analysis of matrix metalloproteinases by immunocytochemistry, immunohistochemistry and zymography in human primary brain tumours. International Journal of Oncology. ,vol. 13, pp. 1153- 1157 ,(1998) , 10.3892/IJO.13.6.1153
Satoshi Nakasu, Asao Hirano, Toshiro Shimura, Josefina F. Llena, Incidental meningiomas in autopsy study. Surgical Neurology. ,vol. 27, pp. 319- 322 ,(1987) , 10.1016/0090-3019(87)90005-X
Mikala Egeblad, Zena Werb, New functions for the matrix metalloproteinases in cancer progression Nature Reviews Cancer. ,vol. 2, pp. 161- 174 ,(2002) , 10.1038/NRC745