Expression of matrix metalloproteinases 2 and 9 in meningiomas associated with different degrees of brain invasiveness and edema.

作者: Ann-Christin Sandberg Nordqvist , Hubert Smurawa , Tiit Mathiesen

DOI: 10.3171/JNS.2001.95.5.0839

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摘要: Object. Meningiomas display clinical characteristics that vary from very benign to clearly malignant with rapid invasive growth and metastasis. Benign meningiomas differ in their invasiveness concomitant edema. This study was undertaken analyze the expression of matrix metalloproteinases 2 9 (MMP-2 MMP-9, respectively) associated different degrees brain invasion Methods. Tissue samples 16 were selected according tumor a consecutive series patients. Samples analyzed for both MMP-2 MMP-9 by using situ hybridization. The consisted three types: Group I, did not interfere arachnoid plane exhibited no edema; II, invaded caused III, aggressive edema displayed invasion. In all tumors analyzed, mRNA identified. Levels o...

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