Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption.

作者: James L. Rubenstein , Jin Kim , Tomoko Ozawa , Michael Zhang , Manfred Westphal

DOI: 10.1038/SJ.NEO.7900102

关键词:

摘要: … While genetic manipulation of VEGF/VEGF receptor expression has previously been shown to inhibit glioblastoma growth, to date, no study has examined the efficacy of pharmacologic …

参考文章(24)
Laurie M. Strawn, Birgit Millauer, Karl H. Plate, Werner Risau, Laura K. Shawver, Michael P. Longhi, Axel Ullrich, Dominant-Negative Inhibition of Flk-1 Suppresses the Growth of Many Tumor Types in Vivo Cancer Research. ,vol. 56, pp. 1615- 1620 ,(1996)
Karl H. Plate, Georg Breier, Herbert A. Weich, Werner Risau, Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature. ,vol. 359, pp. 845- 848 ,(1992) , 10.1038/359845A0
Leonard G Presta, Helen Chen, Shane J O'connor, V Chisholm, Y Gloria Meng, Lynne Krummen, Marjorie Winkler, Napoleone Ferrara, None, Humanization of an Anti-Vascular Endothelial Growth Factor Monoclonal Antibody for the Therapy of Solid Tumors and Other Disorders Cancer Research. ,vol. 57, pp. 4593- 4599 ,(1997)
C.L. Gladson, D.A. Cheresh, J.N. Wilcox, G.Y. Gillespie, L. Sanders, Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. Journal of Cell Science. ,vol. 108, pp. 947- 956 ,(1995) , 10.1242/JCS.108.3.947
P. Hösli, A.P. Sappino, N. de Tribolet, P.Y. Dietrich, Malignant glioma: Should chemotherapy be overthrown by experimental treatments? Annals of Oncology. ,vol. 9, pp. 589- 600 ,(1998) , 10.1023/A:1008267312782
Candelaria Gomez-Manzano, W. K.Alfred Yung, Li Dao Ke, Jeong Soo Kim, Juan Fueyo, Peter A. Steck, Seock Ah Im, Athanassios P. Kyritsis, Ta Jen Liu, Ho Young Lee, Antiangiogenesis treatment for gliomas : Transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo Cancer Research. ,vol. 59, pp. 895- 900 ,(1999)
Patricia A. Stewart, Kay Hayakawa, Catherine L. Farrell, Rolando F. Del Maestro, Quantitative study of microvessel ultrastructure in human peritumoral brain tissue: Evidence for a blood-brain barrier defect Journal of Neurosurgery. ,vol. 67, pp. 697- 705 ,(1987) , 10.3171/JNS.1987.67.5.0697
Shizuo Shirai, Shingo Takano, Hideo Suzuki, Shinichi Kondo, Tooru Maruno, Yoshihiko Yoshii, Tadao Nose, Concentration of Vascular Endothelial Growth Factor in the Serum and Tumor Tissue of Brain Tumor Patients Cancer Research. ,vol. 56, pp. 2185- 2190 ,(1996)
Ken Samoto, Tadahisa Shono, Mayumi Ono, Michihiko Kuwano, Masashi Fukui, Kiyonobu Ikezaki, Kimitoshi Kohno, Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Cancer Research. ,vol. 55, pp. 1189- 1193 ,(1995)