A proton magnetic resonance spectral study of heparin. : L-Iduronic acid residues in commercial heparins

摘要: Abstract The p.m.r. spectra of commercial heparin samples from a variety sources indicate that there are at least two types heparin. These differentiated by small, but distinct, variations in the relative intensities their proton signals and, most noticeably, presence acetyl groups one types. spectral data also approximately equimolar proportions three kinds constituent sugar residues present all samples. Deaminative degradation heparin, followed exhaustive reduction carboxyl groups, acetolysis, and deacetylation, yielded L -idose as major product. It is tentatively concluded -idosyluronic acid constitute about one-third sugars heparins, aminodeoxy- D -hexosyl -glucosyluronic (already recognized constituents) each polymeric material.