Crystalline Structure of Heparin

作者: Edward D. T. Atkins , Ian A. Nieduszynski

DOI: 10.1007/978-1-4684-0946-8_2

关键词:

摘要: Current trends in molecular biology argue convincingly favor of a precise relation between biologic function and shape macromolecules. This is especially relevant the case heparin; evidence points to specific inhibition by this highly charged polysaccharide protein molecules involved blood coagulation. Thus, information concerning structure heparin molecule should be considered as an essential step forward understanding mechanisms

参考文章(33)
Ulf Lindahl, Gudrun Bäckström, Leif Jansson, Anund Hallén, Biosynthesis of Heparin II. FORMATION OF SULFAMINO GROUPS Journal of Biological Chemistry. ,vol. 248, pp. 7234- 7241 ,(1973) , 10.1016/S0021-9258(19)43383-8
Ulf Lindahl, Ove Axelsson, Identification of Iduronic Acid as the Major Sulfated Uronic Acid of Heparin Journal of Biological Chemistry. ,vol. 246, pp. 74- 82 ,(1971) , 10.1016/S0021-9258(18)62534-7
Torsten Helting, Ulf Lindahl, Occurrence and Biosynthesis of β-Glucuronidic Linkages in Heparin Journal of Biological Chemistry. ,vol. 246, pp. 5442- 5447 ,(1971) , 10.1016/S0021-9258(18)61926-X
Magnus HÖÖk, Ulf Lindahl, Per-Henrik Iverius, Distribution of sulphate and iduronic acid residues in heparin and heparan sulphate Biochemical Journal. ,vol. 137, pp. 33- 43 ,(1974) , 10.1042/BJ1370033
A. A. Horner, Enzymic Depolymerization of Macromolecular Heparin as a Factor in Control of Lipoprotein Lipase Activity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 69, pp. 3469- 3473 ,(1972) , 10.1073/PNAS.69.11.3469
R. L. Taylor, J. E. Shively, H. E. Conrad, J. A. Cifonelli, Uronic acid composition of heparins and heparan sulfates Biochemistry. ,vol. 12, pp. 3633- 3637 ,(1973) , 10.1021/BI00743A010
Ulf Lindahl, Gudrun Bäckström, Anders Malmström, Lars-Åke Fransson, Biosynthesis of L-iduronic acid in heparin: Epimerization of D-glucuronic acid on the polymer level Biochemical and Biophysical Research Communications. ,vol. 46, pp. 985- 991 ,(1972) , 10.1016/S0006-291X(72)80238-9