Epstein–Barr virus latent membrane protein 2A mediated activation of Sonic Hedgehog pathway induces HLA class Ia downregulation in gastric cancer cells
作者： Anindita Deb Pal , Subrata Banerjee
DOI: 10.1016/J.VIROL.2015.05.007
关键词:
摘要: One of the immune evasion strategies manifested by malignant cells is downregulation Human Leukocyte Antigen (HLA). HLA Class I (HLA- A, -B, -C) present endogenous peptides including viral and tumor antigens to cytotoxic T lymphocytes for mediated destruction. We have found Epstein Barr Virus (EBV) Latent Membrane Protein 2A (LMP2A) be responsible this in gastric cancer cells. Our results further indicate Sonic Hedgehog pathway; primarily Gli1 bring about LMP2A decrease expression.
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sci-hub.se 参考文章(35)
Francesco M. Marincola, Elizabeth M. Jaffee, Daniel J. Hicklin, Soldano Ferrone, Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Advances in Immunology. ,vol. 74, pp. 181- 273 ,(2000) , 10.1016/S0065-2776(08)60911-6
Karl Erik Hellström, George Klein, Eva Klein, Hans Olof Sjögren, Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host. Cancer Research. ,vol. 20, pp. 1561- 1572 ,(1960)
Rebecca J Port, Sonia Pinheiro-Maia, Chunfang Hu, John R Arrand, Wenbin Wei, Lawrence S Young, Christopher W Dawson, Epstein–Barr virus induction of the Hedgehog signalling pathway imposes a stem cell phenotype on human epithelial cells The Journal of Pathology. ,vol. 231, pp. 367- 377 ,(2013) , 10.1002/PATH.4245
R Khanna, S R Burrows, D J Moss, S L Silins, Peptide transporter (TAP-1 and TAP-2)-independent endogenous processing of Epstein-Barr virus (EBV) latent membrane protein 2A: implications for cytotoxic T-lymphocyte control of EBV-associated malignancies. Journal of Virology. ,vol. 70, pp. 5357- 5362 ,(1996) , 10.1128/JVI.70.8.5357-5362.1996
Aditi Sengupta Banerjee, Anindita Deb Pal, Subrata Banerjee, Epstein–Barr virus-encoded small non-coding RNAs induce cancer cell chemoresistance and migration Virology. ,vol. 443, pp. 294- 305 ,(2013) , 10.1016/J.VIROL.2013.05.020
Lawrence Lum, Philip A Beachy, The Hedgehog Response Network: Sensors, Switches, and Routers Science. ,vol. 304, pp. 1755- 1759 ,(2004) , 10.1126/SCIENCE.1098020
K Takada, Epstein-Barr virus and gastric carcinoma. Journal of Clinical Pathology-molecular Pathology. ,vol. 53, pp. 255- 261 ,(2000) , 10.1136/MP.53.5.255
Nirmal Dutta, Arnab Gupta, Debendra Nath Guha Mazumder, Subrata Banerjee, Down-regulation of locus-specific human lymphocyte antigen class I expression in Epstein-Barr virus-associated gastric cancer: implication for viral-induced immune evasion. Cancer. ,vol. 106, pp. 1685- 1693 ,(2006) , 10.1002/CNCR.21784
Lijun Shen, Alan K.S. Chiang, Wei Ping Liu, Gan Di Li, Raymond H.S. Liang, Gopesh Srivastava, Expression of HLA class I, β2-microglobulin, TAP1 and IL-10 in epstein-barr virus-associated nasal NK/T-cell lymphoma: Implications for tumor immune escape mechanism International Journal of Cancer. ,vol. 92, pp. 692- 696 ,(2001) , 10.1002/1097-0215(20010601)92:5<692::AID-IJC1237>3.0.CO;2-Z
Klaus Fruh, Albrecht Gruhler, Raman Murli Krishna, Gary J. Schoenhals, A comparison of viral immune escape strategies targeting the MHC class I assembly pathway Immunological Reviews. ,vol. 168, pp. 157- 166 ,(1999) , 10.1111/J.1600-065X.1999.TB01290.X