Involvement of eicosanoids in the pathogenesis of pancreatic cancer: The roles of cyclooxygenase-2 and 5-lipoxygenase

摘要: The interplay between inflammation and cancer progression is a growing area of research. A combination clinical, epidemiological, basic science investigations indicate that there relationship inflammatory changes in the pancreas neoplastic progression. Diets high ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2 (COX-2) 5-lipoxygenase (5-LOX) to form eicosanoids. These eicosanoids directly contribute pancreatic cell proliferation. Both COX-2 5-LOX are upregulated multiple types, including cancer. In vitro studies using lines have demonstrated upregulation at both mRNA protein levels. When blocked via variety mechanisms, proliferation abrogated vivo. mechanism has been shown include effects on apoptosis as well angiogenesis. implicated apoptosis. use inhibitors clinical patients with limited. Patient enrollment restricted those advanced disease which makes evaluation these drugs chemopreventive agents difficult. expression be present during early cancer, before invasive disease. This indicates ideal role interventions process preventive agents, perhaps chronic pancreatitis or hereditary pancreatitis.