Lipid metabolic reprogramming in cancer cells

摘要: Many human diseases, including metabolic, immune and central nervous system disorders, as well cancer, are the consequence of an alteration in lipid metabolic enzymes their pathways. This illustrates fundamental role played by lipids maintaining membrane homeostasis normal function healthy cells. We reviewed major dysfunctions occurring during tumor development, determined using systems biology approaches. In it, we provide detailed insight into essential roles exerted specific mediating intracellular oncogenic signaling, endoplasmic reticulum stress bidirectional crosstalk between cells microenvironment cancer Finally, summarize advances ongoing research aimed at exploiting dependency on to abolish progression.