IgG4-reactive low molecular weight antigens from Setaria digitata adult parasites have immunodiagnostic potential in lymphatic filariasis
作者： B. P. Mohanty , S. K. Kar , S. K. Dalai
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摘要: Development of sensitive as well low-cost immuno-diagnostics for detection infected individuals would be an important step towards reaching the goal lymphatic filariasis elimination by 2020. In earlier study, using soluble antigens adult Setaria digitata, we have shown that antigen fraction in molecular weight range 14 to 20 kDa can induce differential Thl/ Th2 immune response PBMC endemic normal (EN) and asymptomatic microfilaraemic (ASM) residing bancroftian areas. present 2D immunoblot are able show two 17 18 pI 5-5.5 recognized IgG4 isotype antibodies, a marker active parasite infection, sera ASM but not EN individuals. Elevated antigen-specific antibodies blood indicators circulating who do apparent clinical symptoms filariasis. Thus, suggest these explored immunodiagnosis
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