Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1.

摘要: Abstract In a previous study (Y. Koga, M. Sasaki, H. Yoshida, Wigzell, G. Kimura, and K. Nomoto, J. Immunol. 144:94-102, 1990), we demonstrated that the expression of gp160, precursor form envelope glycoprotein human immunodeficiency virus type 1, in CD4+ cells causes downregulation surface CD4 single-cell killing by forming intracellular gp160-CD4 complex. In present investigated events lead to cell death expressing gp160. We found apoptosis is induced undergoing death. Moreover, even clone, which expresses so little gp160 it does not exhibit any apparent cytopathic effects, such as inhibition growth, was be highly susceptible induction anti-Fas monoclonal antibody.