Different mechanisms of chromosome 16 loss of heterozygosity in well- versus poorly differentiated ductal breast cancer
作者： Anne-Marie Cleton-Jansen , Horst Buerger , Natalja ter Haar , Katja Philippo , Marc J. van de Vijver
DOI: 10.1002/GCC.20070
关键词:
摘要: Loss of heterozygosity (LOH) at the long arm chromosome 16 is a frequent genetic alteration in breast cancer. It can occur by physical loss part or entire chromosomal arm, resulting decrease copy number followed mitotic recombination. Comparative genomic hybridization (CGH) demonstrated that well-differentiated tumors showed significantly more 16q than did poorly differentiated ones and this difference was already discernable preinvasive stage. However, polymorphic markers detected no frequency LOH between invasive different histological grade. Here, combining data on (n=52), fluorescence situ (n=18) with 16-specific probes, CGH (n=34), we show preference grade I for 16q, whereas III accompanied This clarifies discrepancies observed These somatic mechanisms may reflect presence multiple tumor suppressor genes are target 16q.
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