Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release: A biomechanical, histological, and genetic analysis

摘要: Aims Animal models have been developed that allow simulation of post-traumatic joint contracture. One such model involves contracture-forming surgery followed by surgical capsular release. This allows testing antifibrotic agents, as rosiglitazone. Methods A total 20 rabbits underwent surgery. Eight weeks later, the animals a Ten received rosiglitazone (intramuscular initially, then orally). The were sacrificed following 16 free cage mobilisation. joints tested biomechanically, and posterior capsule was assessed histologically via genetic microarray analysis. Results There no significant difference in contracture between control groups (33° (standard deviation (sd) 11) vs 37° (sd14), respectively; p = 0.4). number or percentage myofibroblasts. Importantly, there ten genes 17 pathways significantly modulated capsule. Discussion Rosiglitazone altered expression tissue rabbit model, with demonstrating modulation. However, effect on biomechanical histological properties. Cite this article: M. P. Abdel. Effectiveness reducing flexion arthrofibrosis release: biomechanical, histological, Bone Joint Res 2016;5:11–17. doi: 10.1302/2046-3758.51.2000593