Pyridazinone compounds and their use as daao inhibitors
作者： Charlotte Fieldhouse , Katherine Hazel , William Farnaby , David Livermore , Catrina Kerr
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摘要: Provided are pyridazinone derivative compounds, of the general formula (I), wherein variables as defined in specification. Examples compounds include 4-Hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one and 6-{ 2-[3-Fluoro-4-(trifluoromethyl)phenyl]ethyl} -4-hydroxy-2,3-dihydropyridazin-3-one. The inhibitors D-amino acid oxidase enzyme (DAAO). may be useful treatment schizophrenia, schizophreniform disorder, schizoaffective cognitive disorders or pain.
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