Use of known compounds as d-amino acid oxidase inhibitors

摘要: The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing finds new uses other than the original medical indications of existing drugs. Finding such will benefit patients who are in needs a potential sooner since known usually with acceptable safety and pharmacokinetic profiles. In this study, marketed DAAO inhibitor schizophrenia was performed on its metabolites. identified available compounds were further confirmed vitro enzymatic inhibitory assay.