Quantitative imaging of Plasmodium transmission from mosquito to mammal
作者： Rogerio Amino , Sabine Thiberge , Béatrice Martin , Susanna Celli , Spencer Shorte
DOI: 10.1038/NM1350
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摘要: Plasmodium, the parasite that causes malaria, is transmitted by a mosquito into dermis and must reach liver before infecting erythrocytes causing disease. We present here quantitative, real-time analysis of fate parasites in rodent system. show only proportion enter blood capillaries, whereas others are drained lymphatics. Lymph sporozoites stop at proximal lymph node, where most degraded inside dendritic leucocytes, but some can partially differentiate exoerythrocytic stages. This previously unrecognized step life cycle could influence immune response host, may have implications for vaccination strategies against preerythrocytic stages parasite.
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