Analysis of Liver Stage Development in and Merozoite Release from Hepatocytes
作者： Rebecca R. Stanway , Jacqueline Schmuckli-Maurer , Volker T. Heussler
DOI: 10.1007/978-1-62703-026-7_29
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摘要: Exoerythrocytic Plasmodium parasites infect hepatocytes and develop to huge multinucleated schizonts inside a parasitophorous vacuole. Finally, thousands of merozoites are formed released into the host cell cytoplasm by complete disintegration vacuole membrane. This, in turn, results death detachment infected hepatocyte, followed formation merosomes. The fast growth parasite hallmarks liver stage development can easily be monitored. Here, we describe how translate these observations assays for characterizing development. Additionally, other recently introduced techniques tools analyze manipulate also discussed.
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