Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids
作者： Angelika Sturm , Rogerio Amino , Claudia Van de Sand , Tommy Regen , Silke Retzlaff
关键词:
摘要: The merozoite stage of the malaria parasite that infects erythrocytes and causes symptoms disease is initially formed inside host hepatocytes. However, mechanism by which hepatic merozoites reach blood vessels (sinusoids) in liver escape immune system before invading remains unknown. Here, we show parasites induce death detachment their hepatocytes, followed budding parasite-filled vesicles (merosomes) into sinusoid lumen. Parasites simultaneously inhibit exposure phosphatidylserine on outer leaflet plasma membranes, act as "eat me" signals to phagocytes. Thus, hepatocyte-derived merosomes appear ensure both migration bloodstream protection from immunity.
sciencemag.org
harvard.edu
core.ac.uk参考文章(12)
Giancarlo A Biagini, Patrick G Bray, David G Spiller, Michael RH White, Stephen A Ward, None, The digestive food vacuole of the malaria parasite is a dynamic intracellular Ca2+ store Journal of Biological Chemistry. ,vol. 278, pp. 27910- 27915 ,(2003) , 10.1074/JBC.M304193200
Ute Frevert, Sabine Engelmann, Sergine Zougbédé, Jörg Stange, Bruce Ng, Kai Matuschewski, Leonard Liebes, Herman Yee, Intravital Observation of Plasmodium berghei Sporozoite Infection of the Liver PLOS Biology. ,vol. 3, ,(2005) , 10.1371/JOURNAL.PBIO.0030192
Rogerio Amino, Sabine Thiberge, Béatrice Martin, Susanna Celli, Spencer Shorte, Friedrich Frischknecht, Robert Ménard, Quantitative imaging of Plasmodium transmission from mosquito to mammal Nature Medicine. ,vol. 12, pp. 220- 224 ,(2006) , 10.1038/NM1350
Ramya Natarajan, Vandana Thathy, Maria M. Mota, Julius C. R. Hafalla, Robert Ménard, Kenneth D. Vernick, Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: a new tool to study mosquito and mammalian host interactions with malaria parasites. Cellular Microbiology. ,vol. 3, pp. 371- 379 ,(2001) , 10.1046/J.1462-5822.2001.00117.X
Blandine Franke-Fayard, Holly Trueman, Jai Ramesar, Jacqui Mendoza, Maarten van der Keur, Reinier van der Linden, Robert E. Sinden, Andrew P. Waters, Chris J. Janse, A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle Molecular and Biochemical Parasitology. ,vol. 137, pp. 23- 33 ,(2004) , 10.1016/J.MOLBIOPARA.2004.04.007
Ming O Li, Matthew R Sarkisian, Wajahat Z Mehal, Pasko Rakic, Richard A Flavell, Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells Science. ,vol. 302, pp. 1560- 1563 ,(2003) , 10.1126/SCIENCE.1087621
J. A. TERZAKIS, J. P. VANDERBERG, D. FOLEY, S. SHUSTAK, Exoerythrocytic Merozoites of Plasmodium berghei in Rat Hepatic Kupffer Cells Journal of Eukaryotic Microbiology. ,vol. 26, pp. 385- 389 ,(1979) , 10.1111/J.1550-7408.1979.TB04641.X
Valerie A. Fadok, Aimee de Cathelineau, David L. Daleke, Peter M. Henson, Donna L. Bratton, Loss of Phospholipid Asymmetry and Surface Exposure of Phosphatidylserine Is Required for Phagocytosis of Apoptotic Cells by Macrophages and Fibroblasts Journal of Biological Chemistry. ,vol. 276, pp. 1071- 1077 ,(2001) , 10.1074/JBC.M003649200
Mois�s Wasserman, Jean Paul Vernot, Paula M. Mendoza, Role of calcium and erythrocyte cytoskeleton phosphorylation in the invasion of Plasmodium falciparum. Parasitology Research. ,vol. 76, pp. 681- 688 ,(1990) , 10.1007/BF00931087
B Verhoven, R A Schlegel, P Williamson, Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. Journal of Experimental Medicine. ,vol. 182, pp. 1597- 1601 ,(1995) , 10.1084/JEM.182.5.1597