Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells
作者： Ming O Li , Matthew R Sarkisian , Wajahat Z Mehal , Pasko Rakic , Richard A Flavell
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摘要: Cells undergoing apoptosis during development are removed by phagocytes, but the underlying mechanisms of this process not fully understood. Phagocytes lacking phosphatidylserine receptor (PSR) were defective in removing apoptotic cells. Consequently, PSR-deficient mice, dead cells accumulated lung and brain, causing abnormal leading to neonatal lethality. A fraction PSR knockout mice manifested a hyperplasic brain phenotype resembling that deficient cell death-associated genes encoding Apaf-1, caspase-3, caspase-9, which suggests phagocytes may also be involved promoting apoptosis. These data demonstrate critical role for early stages mammalian organogenesis suggest respiratory distress syndromes congenital malformations.
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