Recombinant antibodies to the vascular endothelial growth factor (vegf) which are obtained by means of mutagenesis of variable regions
作者： Marta Ayala Avila , Gertrudis Rojas Dorantes , Jorge Victor Gavilondo Cowley , Humberto Lamdan Ordas , Yasmiana Muñoz Pozo
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摘要: The present invention reveals human recombinant antibodies that recognize the Vascular Endothelium Growth Factor A (VEGF-A), block its interaction with VEGFR2 receptor, and interfere proliferative effect in vitro pro-angiogenic vivo. identify an epitope on VEGF-A different from any other previously reported, were obtained by combining one immunoglobulin light chain variable region three heavy ones. mutagenesis, can be employed for immunotherapy of pathological entities associated increase vasculature, such as age-related macular degeneration, cancer, others.
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