METHOD FOR IMPROVING INHIBITION OF VEGF-BINDING TO VEGF-R1 OF AN ANTI-VEGF ANTIBODY

摘要: The present invention relates to methods for modulating anti-VEGF antibodies in order provide variants of an antibody that exhibit improved inhibition VEGF binding VEGF-R1; and provided by said methods. crystal structure the VEGF-0089 Fab fragment complex with VEGF-A121 is disclosed epitope bound was identified. VEGF- 0089 overlaps region binds VEGF-R1 VEGF-R2. VEFG- R1 weaker than Ranibizumab. modified facilitate simultaneous two molecules VEGF-dimer. VEGF-0112, VEGF-P1AD8674 were generated resulting enhanced as compared VEGF-00089 antibody.