P53, p63 and Ki-67 assessment in HPV-induced cervical neoplasia.

摘要: Carcinoma of the uterine cervix is most frequent malignancy in women, with an incidence approximately 456.000 cases per year, leading to 200.000 deaths year. Twenty-six archived formalin-fixed paraffin-embedded samples squamous cell carcinoma, selected from 30 Papanicolaou-positive smears, have been analyzed using standard HE stain and IHC indirect tristadial ABC peroxidase method for four antibodies: p53, p63, Ki-67, HPV. Statistical analysis has done Student t-test, one-group two tails, "paired mean" variant. Two thirds were medium poor differentiated carcinomas. The expression pattern proliferation prognostic factors was biologically correlated histopathological type HPV-infection. statistically significant correlations found between p63 Ki-67 p53 (p<0.001). increase immunomarkers observed late stage cervical neoplasm. P63, followed by showed better correlation cancer progression than p53. This observation could be used clinical practice purpose identifying those patients requiring more aggressive treatment.