Pseudo-Cushing Syndrome

作者: Theodore Friedman

DOI: 10.1007/978-1-59259-101-5_15

关键词:

摘要: Cushing’s syndrome is a rare disorder that can severely affect the patient. It result of prolonged exposure to high levels exogenous or endogenous glucocorticoids. Symptoms patients with include weight gain, easy bruising, menstrual irregularities, increased appetite, trouble sleeping, depression mood swings, anxiety, fatigue and altered mentation (trouble concentrating decreased memory) (1–3). Physical abnormalities new onset obesity (primarily in abdominal buttock regions), buffalo hump, filling regions above collarbone, thinning extremities, rounding reddening face, thin skin, muscle strength, blood pressure, stretch marks, excess hair growth women. Although some may have most all these signs symptoms so diagnosis be make, other mild go their health care providers at an early stage disease. This especially true as has been publicized lay literature, (4) proliferation Internet-related information sites support groups, more are aware explain medical problems. Thus, seeking attention earlier. However, conditions also signs, symptoms, laboratory seen syndrome, without patient actually having syndrome. These called pseudo-Cushing’s states such severe stresses (illness emotional stress), alcoholism alcohol withdrawal, psychiatric depression, panic disorders, psychotic conditions. The pathophysiology leading cortisol production discussed later. Pseudo-Cushing’s classically defined those associated [usually measured by urinary-free (UFC) measurements], but less clinical than Resolution underlying primary condition leads disappearance In this chapter, we will discuss mimic stigmata lack elevated production.

参考文章(103)
Jack A. Yanovski, Gordon B. Cutler, Glucocorticoid Action and the Clinical Features of Cushing’s Syndrome Endocrinology and Metabolism Clinics of North America. ,vol. 23, pp. 487- 509 ,(1994) , 10.1016/S0889-8529(18)30080-X
Bernard J. Carroll, A Specific Laboratory Test for the Diagnosis of Melancholia Archives of General Psychiatry. ,vol. 38, pp. 15- 22 ,(1981) , 10.1001/ARCHPSYC.1981.01780260017001
GEORGE P CHROUSOS, THOMAS H SCHUERMEYER, JOHN DOPPMAN, EDWARD H OLDFIELD, HEINRICH M SCHULTE, PHILIP W GOLD, D LYNN LORIAUX, Clinical Applications of Corticotropin-Releasing Factor Annals of Internal Medicine. ,vol. 102, pp. 344- 358 ,(1985) , 10.7326/0003-4819-102-3-344
P J Wood, J H Barth, D B Freedman, L Perry, B Sheridan, Evidence for the Low Dose Dexamethasone Suppression Test to Screen for Cushing's Syndrome—Recommendations for a Protocol for Biochemistry Laboratories: Annals of Clinical Biochemistry. ,vol. 34, pp. 222- 229 ,(1997) , 10.1177/000456329703400302
Bruno Ambrosi, D. Bochicchio, R. Ferrario, P. Colombo, G. Faglia, Effects of the opiate agonist loperamide on pituitary-adrenal function in patients with suspected hypercortisolism Journal of Endocrinological Investigation. ,vol. 12, pp. 31- 35 ,(1989) , 10.1007/BF03349913
Jack A. Yanovski, Gordon B. Cutler, George P. Chrousos, Lynnette K. Nieman, The Dexamethasone-Suppressed Corticotropin-Releasing Hormone Stimulation Test Differentiates Mild Cushing’s Disease from Normal Physiology The Journal of Clinical Endocrinology and Metabolism. ,vol. 83, pp. 348- 352 ,(1998) , 10.1210/JCEM.83.2.4568
Barbara W. Lex, James E. Ellingboe, Siew Koon Teoh, Jack H. Mendelson, Erin Rhoades, Prolactin and cortisol levels following acute alcohol challenges in women with and without a family history of alcoholism Alcohol. ,vol. 8, pp. 383- 387 ,(1991) , 10.1016/0741-8329(91)90618-7
Monique S. Roy, Alec Roy, William T. Gallucci, Bronwyn Collier, Kim Young, Themis C. Kamilaris, George P. Chrousos, The ovine corticotropin-releasing hormone-stimulation test in type I diabetic patients and controls: suggestion of mild chronic hypercortisolism. Metabolism-clinical and Experimental. ,vol. 42, pp. 696- 700 ,(1993) , 10.1016/0026-0495(93)90235-G
Anthony Smals, Peter Kloppenborg, ALCOHOL-INDUCED PSEUDO-CUSHING'S SYNDROME The Lancet. ,vol. 309, pp. 1369- 1369 ,(1977) , 10.1016/S0140-6736(77)92586-7
G. P. Bernini, G. F. Argenio, F. Cerri, F. Franchi, Comparison between the suppressive effects of dexamethasone and loperamide on cortisol and ACTH secretion in some pathological conditions Journal of Endocrinological Investigation. ,vol. 17, pp. 799- 804 ,(1994) , 10.1007/BF03347780