摘要: Cushing’s syndrome is a rare disorder that can severely affect the patient. It result of prolonged exposure to high levels exogenous or endogenous glucocorticoids. Symptoms patients with include weight gain, easy bruising, menstrual irregularities, increased appetite, trouble sleeping, depression mood swings, anxiety, fatigue and altered mentation (trouble concentrating decreased memory) (1–3). Physical abnormalities new onset obesity (primarily in abdominal buttock regions), buffalo hump, filling regions above collarbone, thinning extremities, rounding reddening face, thin skin, muscle strength, blood pressure, stretch marks, excess hair growth women. Although some may have most all these signs symptoms so diagnosis be make, other mild go their health care providers at an early stage disease. This especially true as has been publicized lay literature, (4) proliferation Internet-related information sites support groups, more are aware explain medical problems. Thus, seeking attention earlier. However, conditions also signs, symptoms, laboratory seen syndrome, without patient actually having syndrome. These called pseudo-Cushing’s states such severe stresses (illness emotional stress), alcoholism alcohol withdrawal, psychiatric depression, panic disorders, psychotic conditions. The pathophysiology leading cortisol production discussed later. Pseudo-Cushing’s classically defined those associated [usually measured by urinary-free (UFC) measurements], but less clinical than Resolution underlying primary condition leads disappearance In this chapter, we will discuss mimic stigmata lack elevated production.