Inversion recovery MRI in idiopathic Parkinson disease is a very sensitive tool to assess neurodegeneration in the substantia nigra: preliminary investigation.

摘要: Rationale and Objectives Segmented inversion recovery (IR) ratio imaging (SIRRIM) has been established as a sensitive tool to assess neurodegeneration of the substantia nigra pars compacta (SNC) in patients with idiopathic Parkinson disease (IPD). The obtained results suggest possibility magnetic resonance (MRI) biological marker for IPD. strength parsimonious analysis technique are discussed potential using MRI IPD improve differential diagnosis sporadic disease. Our hypothesis states that SIRRIM allows direct visualization quantitation neural cell loss SNC therefore could become reliable To achieve this goal, some key aspects data acquisition need be addressed. clinical impact considerable, considering it might viable surrogate other techniques. Patients Methods Twelve 12 age-matched control subjects were imaged by based on two IR sequences designed suppress white gray matter cells situ means image (white suppressed image). radiological index was correlated Unified Disease Rating Scale (UPDRS) Results All identified correctly, full dichotomization between healthy volunteers our database. shows can used rule out from essential tremor forms Parkinsonism, such progressive supranuclear palsy multisystem atrophy. In addition, is enough identify early-stage Conclusion supported excellent correlation UPDRS scoring proved useful evaluation technique, showing, improved. Technical processing addressed overcome. It ultimately confirms objectives achieved us expect assessment development longitudinal studies putative neuroprotective approaches taken during evolution