Death through a tragedy: mitotic catastrophe
作者： H Vakifahmetoglu , M Olsson , B Zhivotovsky
DOI: 10.1038/CDD.2008.47
关键词:
摘要: Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from premature or inappropriate entry cells into mitosis and can be caused by chemical physical stresses. Whereas it initially was depicted the main form induced ionizing radiation, is today known to triggered also treatment with agents influencing stability microtubule, various anticancer drugs mitotic failure defective cycle checkpoints. Although descriptions explaining MC exist, there still no general accepted definition this phenomenon. Here, we present evidences indicating death-associated not separate death, rather process ('prestage') preceding which occur through necrosis apoptosis. The final outcome depends on molecular profile cell.
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