The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells.

摘要: We have determined the genetic structure of Salmonella enterica centisome 7 genomic island (SCI) located at aspV loci in S. subspecies I strains. The 47-kb long encodes 37 putative proteins, including previously described saf fimbrial operon and sinR transcriptional regulator. Other open reading frames (designated sci A to Z) encode proteins with homologies virulence-associated a number gram-negative bacteria such as Pseudomonas aeruginosa, Yersinia pestis enterohemorrhagic Escherichia coli, that ability interact manipulate eukaryotic cells. Sci cytoplasmic, periplasmic outer membrane localizations pointing role extracellular processes secretion or organelle biosynthesis. genes encoding Sci-like are clustered all sequenced bacterial genomes available databases core set can be defined by presence similarity SciB, C, G, H, I, O proteins. SCI DNA sequences restricted strains belonging deletion entire affects organisms enter