Brain activation patterns of versive, hypermotor, and bilateral asymmetric tonic seizures.

摘要: Summary Purpose:  Patients who have seizure onset from different brain regions can produce seizures that appear clinically indistinguishable one another. These stereotypic manifestations reflect epileptic activation of specific networks. Several studies shown ictal perfusion single photon emission computed tomography (SPECT) reveal propagated activity. We hypothesize the pattern hyperperfusion may neuronal networks generated symptomatology. Methods:  All patients were identified injected with 99mTc-hexamethyl-propylene-amine-oxime (HMPAO) during versive (n = 5), bilateral asymmetric tonic (BATS; n = 5), and hypermotor (n = 7) in presurgical epilepsy evaluation between 2001 2005. The SPECT ictal–interictal difference image pairs each subgroup compared 14 controls using statistical parametric mapping (SPM 2) to identify significant hyperperfusion. Hyperperfused corrected cluster-level significance p < 0.05 considered significant. Results:  a distinct subgroup. In subgroup, prominent was present frontal eye field opposite direction head version. addition, there associated caudate crossed cerebellar BATS showed pronounced supplementary sensorimotor area ipsilateral epileptogenic region, basal ganglia, contralateral hemisphere. demonstrated two clusters hyperperfusion: involving frontomesial regions, cingulate gyri, nuclei, another anteromesial temporal structures, frontoorbital insula, ganglia. Discussion:  patterns for symptomatology. Our findings provide further insight into understanding anatomic basis semiology.