摘要: The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In body, TRP is transported around periphery either bound to albumin (90%) or in free form (10%), two states existing equilibrium (McMenamy 1965). However, only can be across blood-brain barrier (BBB) by competitive and nonspecific L-type amino acid transporter (Hargreaves Pardridge 1988). Once central nervous system (CNS), acts as precursor several metabolic pathways, such synthesis (KYN), serotonin, melatonin protein (Fig. 1) (Ruddick et al. 2006).
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sci-hub.se 参考文章(200)
Paula Heron, Santy Daya, 17Beta-estradiol protects against quinolinic acid-induced lipid peroxidation in the rat brain. Metabolic Brain Disease. ,vol. 15, pp. 267- ,(2000) , 10.1023/A:1011119107765
Rapier H. McMenamy, Binding of Indole Analogues to Human Serum Albumin: EFFECTS OF FATTY ACIDS Journal of Biological Chemistry. ,vol. 240, pp. 4235- 4243 ,(1965) , 10.1016/S0021-9258(18)97049-3
R. R. Brown, Y. Ozaki, S. P. Datta, E. C. Borden, P. M. Sondel, D. G. Malone, Implications of Interferon-Induced Tryptophan Catabolism in Cancer, Autoimmune Diseases and Aids Advances in Experimental Medicine and Biology. ,vol. 294, pp. 425- 435 ,(1991) , 10.1007/978-1-4684-5952-4_39
M. P. Heyes, The Kynurenine Pathway and Neurologic Disease Advances in Experimental Medicine and Biology. ,vol. 398, pp. 125- 129 ,(1996) , 10.1007/978-1-4613-0381-7_20
V. Rudzite, E. Jurika, J. Jirgensons, Changes in membrane fluidity induced by tryptophan and its metabolites. Advances in Experimental Medicine and Biology. ,vol. 467, pp. 353- 367 ,(1999) , 10.1007/978-1-4615-4709-9_46
Gilles J. Guillemin, Danielle G. Smith, George A. Smythe, Patricia J. Armati, George J. Brew, Expression of the kynurenine pathway enzymes in human microglia and macrophages. Advances in Experimental Medicine and Biology. ,vol. 527, pp. 105- 112 ,(2003) , 10.1007/978-1-4615-0135-0_12
Flavio Moroni, Andrea Cozzi, Fiamma Peruginelli, Neuroprotective Effects of Kynurenine-3-Hydroxylase Inhibitors in Models of Brain Ischemia Advances in Experimental Medicine and Biology. ,vol. 467, pp. 199- 206 ,(1999) , 10.1007/978-1-4615-4709-9_26
B. Widner, F. Leblhuber, J. Walli, G. P. Tilz, U. Demel, D. Fuchs, Degradation of tryptophan in neurodegenerative disorders. Advances in Experimental Medicine and Biology. ,vol. 467, pp. 133- 138 ,(1999) , 10.1007/978-1-4615-4709-9_19
Russell H Swerdlow, Pathogenesis of Alzheimer’s disease Clinical Interventions in Aging. ,vol. 2, pp. 347- 359 ,(2007)
G. Melillo, M. C. Bosco, T. Musso, L. Varesio, Immunobiology of Picolinic Acid Advances in Experimental Medicine and Biology. ,vol. 398, pp. 135- 141 ,(1996) , 10.1007/978-1-4613-0381-7_22