Neuroprotective Effects of Kynurenine-3-Hydroxylase Inhibitors in Models of Brain Ischemia
作者： Flavio Moroni , Andrea Cozzi , Fiamma Peruginelli
DOI: 10.1007/978-1-4615-4709-9_26
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摘要: The neuroprotective effects of two kynurenine hydroxylase inhibitors, (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048), were studied in vitro vivo. In organotypic hippocampal slice cultures deprived oxygen glucose, these inhibitors significantly reduced neuronal damage. gerbils subjected to bilateral carotid occlusion for 5 min, the administration mNBA (400mg/kg i.p., 3 times) or Ro 61-8048 (40mg/kg dramatically decreased percentage damaged pyramidal neurones CA1 region. Finally, rats with permanent middle cerebral artery, (200-400mg/kg i.p.) infarct volume. Our results demonstrate that ischemic damage may be by inhibiting hydroxylase.
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