Effects of combined radiation and burn injury on the renin-angiotensin system.
作者： Sachin S. Jadhav , Natasha Sharma , Christopher J. Meeks , Nicholas M. Mordwinkin , Theresa B. Espinoza
DOI: 10.1111/J.1524-475X.2012.00867.X
关键词:
摘要: The renin-angiotensin system (RAS) plays an important role in wound repair; however, little is known pertaining to RAS expression response thermal injury and the combination of radiation plus burn (CRBI). purpose this study was test hypothesis that modifies components CRBI delayed up-regulation RAS. Skin from uninjured mice compared with receiving local or (injury site). analyzed for gene protein components. There initial increase various following injury. However, higher group there decrease AT(1b) (vasoconstriction, pro-proliferative), AT(2) (vasodilation, differentiation), Mas anti-inflammatory) expression. This corresponded a delay AT(1) , MAS fibroblasts keratinocytes. reduction receptor positive keratinocytes correlated collagen deposition keratinocyte infiltration into wounded area resulting reepithelialization CRBI. These data support healing observed subjects exposure may be part due decreased
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